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Dolly: The Story of the Famous Sheep That Became a Breakthrough in Species Cloning



After 277 attempts, 6 embryos were born and she was the only one to be born. He quickly achieved worldwide fame, lived like just another sheep, gave birth to six children and died at half the normal lifespan, making him the best-known cloned animal in history. Dolly is still controversial and is considered a tipping point in genetic research that would ultimately lead to advances in stem cells.

sheep dolly – named after country singer Dolly Parton – went down in history as follows. the first animal cloned from an adult cell, And managed to live for 6 years. Its birth alone already generated controversy, expectations and questions that continue to this day.

was born in July 5, 1996, As part of a series of experiments aimed at producing genetically modified cattle, Roslyn Institute From Scotland where it all began.

This process is revolutionary and, in a nutshell, American Museum of Natural History,Next:

They took cells from the genetic mother’s breast and proliferated them, stopping the process when they were sufficiently divided. They then took an egg from another sheep, removed its nucleus, and combined it with one of the mammary cells.

Then I used electricity to fuse them together. The new cells then divided to form an embryo, which was inserted into the third sheep. Five months later, he was born and shocked the world.

Dolly the Sheep in front of the press around the world.
Murdo McLeod | The Roslyn Institute

Scientists kept the event a closely guarded secret until February 22, 1997, when it shocked the world.this is how he remembers National Museum of Scotland.

time He admits that even though the explanation seems simple, the process was very complicated. Of 277 attempts, only 29 of his embryos survived six days or more, and all but Dolly died before birth. Only four researchers and one veterinarian witnessed his birth.

With his arrival, science fiction fantasies became reality. He demonstrated that specialized cells could be used to create exact copies of animals. Controversy erupted: What impact might this process have on cloned animals? Could it be used to save species from extinction? What are the consequences of applying this technology to humans? and help create a form of immortality? Is it possible to build an army of clones? Is it okay to clone?

The Life and Death of Dolly the Cloned Sheep

Dolly spent her entire life with the herd like another sheep, but at the age of one, she was found to have weaker DNA than other sheep of her age, possibly due to genetic damage. .

She was bred with a ram named David. She gave birth to six lambs, Bonnie in 1998, twins Sally and Rosie in 1999, and triplets Lucy, Darcy and Cotton in 2000.

Dolly the sheep undergoing an ultrasound during pregnancy.
Roslyn Institute

A year later, he was spotted walking strangely, was diagnosed with arthritis, and was treated for the condition. This fact, along with the premature death of another cloned sheep from pulmonary adenomatosis the previous year, revived the suspicion that his cloned sheep were aging prematurely.

finally, Dolly the Sheep died on February 14, 2003 at the age of six. -Half a normal lifespan- and was euthanized after it was found to have a tumor growing on his chest, with a lung infection common in animals with no outdoor access. Six days ago, I noticed an employee coughing.

His body was donated to the National Museum of Scotland and is still on display, marking the second anniversary of his death this year.

Ryan Wilmut, one of the scientists who created the cloned sheep Dolly, next to her remains at the National Museum of Scotland.
| Andrew Milligan

one before and one after

yep, OK Dolly wasn’t the first cloned organism (preceded by tadpoles, fish, mice and cows, but other less sophisticated techniques were used and adult animal cells were not involved), 1996 marked a milestone in cloning science, which Some progress has been made since then.

It is detailed that not only sheep but also cows, cats, dogs, horses, rabbits and even monkeys can be cloned. Scientific American and the Deutsche Welle.

Some of them die soon after birth or grow up to develop health problems, confirming concerns that these procedures are far from perfect. However, Dolly’s original purpose – to produce more cattle to produce food – has been achieved, and it is both legal and applicable in some countries, such as the United States.

even if you add BBCa human embryo was cloned in 2001, and ten years later scientists successfully cloned human stem cells.

time He points out that the fears surrounding human cloning never materialized, speculating that there are commercial motives. In a survey conducted by the company, “only 7% of readers said he would be interested in cloning himself if given the chance.”

Ian Wilmut, one of the scientists who cloned Dolly, still thinks it’s a bad idea. They will likely end up in miscarriages or abnormal births. “

He illustrated that one of the lambs cloned after Dolly had a lung problem that caused hyperventilation, which ultimately caused death. “It was painful enough to see it in animals.

But thanks to Dolly’s milestone, we’ve made significant progress. stem cell the creation of new therapies based on them, and other cloning techniques developed more efficiently.

What’s more, he notes that it’s not just about saving species from imminent extinction, it’s being seriously considered. Understanding animal research, but can also “resurrect” already extinct species. The latter, however, is much more complicated as it requires cellular material that is generally no longer accessible.

But science hasn’t stopped, and teams from Japan, Russia and South Korea are already working to revive the woolly mammoth.

Source: Biobiochile

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